• Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...
    • Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study 

      Balteskard Rinde, Ludvig; Lind, Caroline; Småbrekke, Birgit; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Løchen, Maja-Lisa; Mathiesen Hald, Erin; Vik, Anders; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Rinde, Ludvig Balteskard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Background: Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. <p> Objectives: We aimed to study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. <p> Methods: Study participants (n=29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-95, 2001-02 ...
    • Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Evensen, Line Holtet; Morelli, Vania Maris; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Njølstad, Inger; Mathiesen, Ellisiv B.; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-24)
      <i>Background</i>: Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE).<p> <p><i>Objectives</i>: To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case‐cohort recruited from a general population.<p> <p><i>Methods</i>: Cases with a first VTE (<i>n</i> = 1493) and a subcohort (<i>n</i> = ...
    • Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study 

      Balteskard Rinde, Ludvig; Småbrekke, Birgit; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen Hald, Erin; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)
      <i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ...
    • Myocardial infarction and future risk of cancer in the general population—the Tromsø Study 

      Rinde, Ludvig Balteskard; Småbrekke, Birgit; Mathisen Hald, Erin; Brodin, Ellen Elisabeth; Njølstad, Inger; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Vik, Anders; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
      The association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, ...
    • Repeated measurements of carotid atherosclerosis and future risk of venous thromboembolism: the Tromsø Study 

      Småbrekke, Birgit; Rinde, Ludvig Balteskard; Mathisen Hald, Erin; Njølstad, Inger; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas; Lijfering, Willem M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-05)
      <p><i>Background</i>: Whether a relationship between atherosclerosis and subsequent venous thromboembolism (VTE) exists is controversial.</p> <p><i>Objective</i>: To investigate the association between carotid atherosclerosis and VTE by using repeated measurements of intima media thickness (IMT) and total plaque area (TPA) in participants recruited from the general population.</p> <p><i>Methods</i>: ...
    • The Role of Stroke as a Trigger for Incident Venous Thromboembolism: Results from a Population-based Case-Crossover Study 

      Morelli, Vania Maris; Sejrup, Joakim Knutsen; Småbrekke, Birgit; Rinde, Ludvig B; Grimnes, Gro; Isaksen, Trond; Hansen, John-Bjarne; Hindberg, Kristian; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
      Stroke is associated with a short-term increased risk of subsequent venous thromboembolism (VTE). It is unclear to what extent this association is mediated by strokerelated complications that are potential triggers for VTE, such as immobilization and infection. We aimed to investigate the role of acute stroke as a trigger for incident VTE while taking other concomitant VTE triggers into account. ...
    • Shared risk factors for arterial cardiovascular diseases and venous thromboembolism 

      Småbrekke, Birgit (Doctoral thesis; Doktorgradsavhandling, 2019-06-28)
      <i>Summary</i> - Extensive evidence support an association between arterial cardiovascular disease (CVD, i.e. myocardial infarction [MI] and ischemic stroke), and subsequent venous thromboembolism (VTE, i.e. deep vein thrombosis [DVT]) and pulmonary emboli [PE]). However, the mechanism behind the associations remains unclear. The aim of this thesis was to investigate the impact of ischemic stroke ...